The renal protective efficacy of ketamine vs. propofol vs. ketofol against renal ischemia / reperfusion injury: An experimental rat study

The purpose of this study was to investigate the renal protective efficacy propofol, ketamine, and ketofol in an ischemia/reperfusion injury (IRI) model experimentally induced rats. Thirty-five male Sprague-Dawley rats were randomly assigned into five groups: sham (Group 1), control 2), ketamine 3), propofol 4), 5). Following administration intramuscular hydrochloride anesthesia, left hilum exposed 60-minutes clamping. Ketamine 5) administered 15 min prior reperfusion. After six hours reperfusion, kidneys harvested for histological scoring. Mean histopathology scores 0.42±0.53 group 1 (Sham), 2.97±0.21 2 (Control), 2.68±0.15 3 (Ketamine), 2.40±0.16 4 (Propofol), 2.51±0.22 5 (Ketofol). score (Propofol) significantly lower than those groups (control) (Ketamine) (P=.002 P=.0120, respectively), but did not differ from that (Ketofol) (P=.347). compared (P=.006), no significant difference determined with Group (P=.137). No also observed between (P=.021). results indicated superiority over or against IRI. However, effect IRI greater ketamine.